László Őrfi - ODT Personal data sheet


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Personal data sheet

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personal data approved: 2023. XI. 14.

Personal data

name	László Őrfi
name of institution	Budapest University of Technology and Economics Semmelweis University, Budapest
doctoral school	BME George A. Olah Doctoral School of Chemistry and Chemical Technology (Academic staff member Az oktató a doktori iskola doktoranduszai számára oktat tantárgyat, és/vagy a doktori iskola megszavazta, hogy doktoranduszok számára kutatási témát írjon ki. ) (discipline) Habilitation Comittee and Doctoral Council (external member) SE Doctoral School of Molecular Medicine (Academic staff member Az oktató a doktori iskola doktoranduszai számára oktat tantárgyat, és/vagy a doktori iskola megszavazta, hogy doktoranduszok számára kutatási témát írjon ki. ) SE Doctoral School of University Semmelweis (Core member) SE Doctoral School of Pharmaceutical Sciences Council of the Doctoral School
the share of work in the different doctoral schools.	BME George A. Olah Doctoral School of Chemistry and Chemical Technology 10% SE Doctoral School of University Semmelweis 70% BME GAODSCC (discipline) Habilitation Comittee and Doctoral Council (external member) 20%
accreditation statement submitted to:	Semmelweis University, Budapest

Contact details
phone number	+36 1 217-0891
	own web page

Academic title
scientific degree, title	Ph.D.
year degree was obtained	1997
discipline to which degree belongs	chemistry
institution granting the degree	Semmelweis University
scientific degree, title	Habilitation
year degree was obtained	2013
discipline to which degree belongs	pharmaceutics
institution granting the degree	Semmelweis University

Employment
1982 -	Semmelweis University, Budapest university professor or researcher

Thesis topic supervisor

number of doctoral students supervised until now

number of students who fulfilled course requirements

students who obtained their degrees:

Anna Sipos	PhD	2021	DSPS1-SE
Rita Garamvölgyi	PhD	2017	DSPS1-SE
Ferenc Baska	PhD	2015	DSPS1-SE
Gábor Németh	PhD	2012	DSPS1-SE
Gábor Péter Bánhegyi	PhD	2009	DSPS1-SE
Csaba Szántai-Kis	PhD	2008

completed course requirement:

Marcell Krekó	(PhD)	2021/08	DSPS1-SE
Mihály Szabó	(PhD)	2020/08	DSPS1-SE
Zoltán Nemes	(PhD)	2015/08	DSPS1-SE
Zsófia Molnár Balázsné dr. Czudor	(PhD)	2018/08	DSPS1-SE

present PhD students:

Gyula Bencze

(PhD)

(2024/08)

SEDI (to be translated)

Thesis topic proposals

Research
research area	Pharmaceutical chemistry, kinase inhibitors, quantitative structure-activity relationship (QSAR, ADMET), drug design, lead optimisation, drug discovery, medicinal chemistry, paralell synthesis
research field in which current research is conducted	pharmaceutics chemistry

Publications

2021

Szabó Zoltán-István, Orbán György, Borbás Enikő, Csicsák Dóra, Kádár Szabina, Fiser Béla, Dobó Máté, Horváth Péter, Kiss Eszter, Budai Lívia, Dobos Judit, Pálla Tamás, Őrfi László, Völgyi Gergely, Tóth Gergő: Inclusion complexation of the anticancer drug pomalidomide with cyclodextrins: fast dissolution and improved solubility, HELIYON 7: (7) e07581
type of document: Journal paper/Article
number of independent citations: 6
language: English
URL

2021

Bencze Gyula, Bencze Szilvia, Rivera Keith D., Watson James D., Hidvegi Mate, Orfi Laszlo, Tonks Nicholas K., Pappin Darryl J.: Author Correction: Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth (vol 10, 14174, 2020), SCIENTIFIC REPORTS 11: (1) 3036
type of document:
language: English
URL

2018

Zsófia Czudor, Mária Balogh, Péter Bánhegyi, Sándor Boros, Nóra Breza, Judit Dobos, Márk Fábián, Zoltán Horváth, Eszter Illyés, Péter Markó, Anna Sipos, Csaba Szántai-Kis, Bálint Szokol, László Őrfi: Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28: (4) pp. 769-773.
type of document: Journal paper/Article
number of independent citations: 14
language: English
URL

2018

Nemes Zoltán, Takács-Novák Krisztina, Völgyi Gergely, Valko Klara, Béni Szabolcs, Horváth Zoltán, Szokol Bálint, Breza Nóra, Dobos Judit, Szántai-Kis Csaba, Illyés Eszter, Boros Sándor, Kok Robbert Jan, Őrfi László: Synthesis and characterization of amino acid substituted sunitinib analogues for the treatment of AML, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28: (14) pp. 2391-2398.
type of document: Journal paper/Article
number of independent citations: 6
language: English
URL

2018

Szabadkai I, Torka R, Garamvolgyi R, Baska F, Gyulavari P, Boros S, Illyes E, Choidas A, Ullrich A, Orfi L: Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as Novel AXL Kinase Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY 61: (14) pp. 6277-6292.
type of document: Journal paper/Article
number of independent citations: 20
language: English
URL

2016

Garamvolgyi R, Dobos J, Sipos A, Boros S, Illyes E, Baska F, Kekesi L, Szabadkai I, Szantai-Kis C, Keri G, Orfi L: Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells., EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 108: pp. 623-643.
type of document: Journal paper/Article
number of independent citations: 28
language: English
URL

2010

Petak I, Schwab R, Orfi L, Kopper L, Keri G: Integrating molecular diagnostics into anticancer drug discovery, NATURE REVIEWS DRUG DISCOVERY 9: (7) pp. 523-535.
type of document: Journal paper/Article
number of independent citations: 49
language: English
URL

2008

Zhang YX, Knyazev PG, Cheburkin YV, Sharma K, Knyazev YP, Orfi L, Szabadkai I, Daub H, Keri G, Ullrich A: AXL is a potential target for therapeutic intervention in breast cancer progression, CANCER RESEARCH 68: (6) pp. 1905-1915.
type of document: Journal paper/Article
number of independent citations: 181
language: English
URL

2004

Ozvegy-Laczka C, Hegedus T, Varady G, Ujhelly O, Schuetz JD, Varadi A, Keri G, Orfi L, Nemet K, Sarkadi B: High-affinity interaction of tyrosine kinase inhibitors with the ABCG2multidrug transporter, MOLECULAR PHARMACOLOGY 65: (6) pp. 1485-1495.
type of document: Journal paper/Article
number of independent citations: 310
language: English
URL

1998

Orfi L, Lin MF, Larive CK: Measurement of SDS micelle-peptide association using H-1 NMR chemical shift analysis and pulsed field gradient NMR spectroscopy, ANALYTICAL CHEMISTRY 70: (7) pp. 1339-1345.
type of document: Journal paper/Article
number of independent citations: 61
language: English
URL

Number of independent citations to these publications:

675

Scientometric data

list of publications and citations

number of scientific publications that meet accreditation criteria:

337

number of scientific publications:

331

monographs and professional books:

monographs/books in which chapters/sections were contributed:

art/engineering creative works:

scientific publications published abroad that meet the accreditation criteria:

174

publications not in Hungarian, published in Hungary, meeting the accreditation criteria:

number of independent citations to scientific publications and creative works:

3906

further relevant information regarding accreditation (in Hungarian)
Inventor of more than 110 pharmaceutical patents