Új, funkcionálisan szelektív 1-es típusú kannabinoid receptorokon (CB1R) ható alloszterikus modulátorok fejlesztése és jellemzése a kannabinoidok használatához kapcsolód
témavezető: Dvorácskó Szabolcs
helyszín (magyar oldal): HUN-REN Biológiai Kutató Központ helyszín rövidítés: BRC
A kutatási téma leírása:
The endocannabinoid system (ECS) is involved in numerous physiological and pathological processes in the central nervous system and in the periphery. For instance, although CB1R has great therapeutic potential in the treatment of several disorders their clinical translation is limited due to unwanted side effects. Despite the useful effects of plant-derived and synthetic CB1R agonists, their psychoactive effects limit their clinical applications. Furthermore, there are highly potent synthetic CB1R agonists among illicit drugs that are dangerous, occasionally lethal compounds worldwide with distinct, mostly unknown clinical effects and diverse PK/PD. At present there is no specific antidote for the intoxication of such synthetic cannabinoids.
However, recent clinical studies with functionally selective blockade of CB1R to improve safety in metabolic and cannabinoid use disorder. Accordingly, targeting CB1R with functionally selectivity (biased antagonist and/or negative allosteric modulators) may offer the opportunity for developing safer and more effective therapies.
The candidate will be involved in the design, synthesis, and in vitro-, and in vivo pharmacological characterization of novel ligands targeting cannabinoid receptors.
előírt nyelvtudás: angol felvehető hallgatók száma: 1
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