témavezető: Szilágyi Botond
helyszín (magyar oldal): BME Kémiai és Környezeti Folyamatmérnöki Tanszék helyszín rövidítés: BME
A kutatási téma leírása:
Objectives
This Ph.D. project has as its overarching aim the development of generic, design-oriented process models suitable to describe biomolecules crystallisation in batch and continuous platforms. The kinetic and thermodynamic models, which may differ from the typical equations widely used in small molecule crystallisation, will be developed with external parters within the PROCRYSTAL MSCA Doctoral Network project, partially based on their measurements and expertise.
Specific objectives:
1. Develop a process-level kinetic model library for nucleation and growth of biomolecules. This will be realised with a comprehensive literature review and collaboration, including knowledge and data sharing, with other DCs. The library may include first-principle mechanistic models laying on solid physical foundations, and semi-mechanistic models involving fewer parameters, making them easier to identify but less predictive.
2. Develop process models that can simulate batch and continuous crystallisers. Trajectory optimisation to determine the dynamic operation of batch systems, as well as designing multi-segment multi (precipitating agent) addition continuous crystallisers, is a part of this task as well. These will rely on population balance models, with some compartmentalisation in the mixing-critical and high-shear (impeller) regions.
3. Validate experimentally the models using a relevant case study. To mimic the real workflow, the crystallisation kinetics is aimed to be determined from small-scale experiments, and after the successful determination, it will be transferred, after careful analysis, to the manufacturing scale of interest.
4. Develop a digital twin, which will receive PAT measurements from the process, and by re-adjusting itself continuously, it will estimate the otherwise unmeasurable states, becoming a soft sensor with unprecedented capabilities.
Expected Results:
Generic process model of batch and continuous biomolecules crystallisation with thermodynamic and kinetic equations adapted to relevant therapeutic molecules (mAbs, peptides) and a case study
using a model compound (globular protein) with a focus on particle size control and productivity.
felvehető hallgatók száma: 1
Jelentkezési határidő: 2024-05-30
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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