 Protein-glycan core-shell nanocarriers for drug delivery and controlled release TÉMAKIÍRÁS Intézmény: Budapesti Műszaki és Gazdaságtudományi Egyetem kémiai tudományok Oláh György Doktori Iskola (Kémia és Vegyészmérnöki tudományok) témavezető: Imre Balázs helyszín (magyar oldal): BME Fizikai Kémia és Anyagtudományi Tanszék helyszín rövidítés: BME A kutatási téma leírása: We design and synthesize plant protein and synthetic proteinoid nanocarriers with glycan outer shells for the encapsulation and controlled delivery of poorly water-soluble active substances. Poor water solubility and bioavailability limits the efficacy of numerous active substances. Their encapsulation with nanoparticles improves solubility and stability, enabling the use of drug candidates previously ignored due to poor pharmacokinetics. Proteins are non-toxic, biodegradable, and metabolizable natural amphiphilic polymers that form nanoparticles by environmentally benign self-assembly to encapsulate various compounds. Their surface can be conveniently modified with drugs and targeting ligands. In this project, protein-glycan core-shell nanocarriers are prepared by nanoprecipitation and enzymatic cross-linking, following green chemistry principles. In addition to their size distribution, drug encapsulation and release characteristics, we aim to study and mitigate the immune response induced by the nanocarriers in vivo. felvehető hallgatók száma: 1 Jelentkezési határidő: 2024-05-30 |