The lack of physical exercise, the lifestyle of our century, leads to significant increase of numerous cardiovascular and locomotor diseases worldwide. Prevention became a critical task of the scientific and medical society. It is obvious to all, regular training not only ensures health, but may also reverse pathological processes of disease by beneficially enhancing cellular and organ regeneration. Therefore, the primary aim of our current study is to screen and detect the influence of various sport activities on the human body at physiological, cellular and molecular levels. Our goal is to establish a collection of naturally existing secreted small molecules (peptides, micro RNAs, ect.,) and to investigate their effects on tissue regeneration and repair.