Thesis supervisor: Viktória Gasznerné Kormos
Location of studies (in Hungarian): PTE ÁOK Abbreviation of location of studies: ÁOK
Description of the research topic:
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel its endogenous agonists include mediators released during inflammatory and degenerative processes (e.g. lipid peroxidation products, free radicals, fatty acids). Upon activation, Ca2+ influx occurs, which influences intracellular processes and plays an important role in modulating degeneration, inflammation or apoptosis. Literature data suggests that TRPA1 is found in the cornea, the retina and the optic nerve. Our aim is to investigate whether TRPA1 contributes to cornea, retina and optic nerve damage in mouse models of various ocular diseases using complex pharmacokinetic, functional-morphological and molecular biological methods. A deeper understanding of the mechanisms underlying these diseases may bring us closer to identifying new therapeutic targets.
Number of students who can be accepted: 1
Deadline for application: 2025-05-16
2025. IV. 02. ODT ülés Az ODT következő ülésére 2025. május 30-án, pénteken 10.00 órakor kerül sor a BC22 irodaház Marcus Aurelius termében (1085 Bp. Baross u. 22. földszint).
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