Thesis supervisor: Erika Bálint
Location of studies (in Hungarian): BME Szerves Kémia és Technológia Tanszék Abbreviation of location of studies: BME
Description of the research topic:
Small molecule inhibitors (SMIs) are one of the primary targeted therapies for cancer diseases. Many efforts have been devoted to the development of several SMIs due to the advantages in a wide range of targets, convenient drug treatment, and ability to penetrate into the central nervous system.
The aim of this project is to design and synthesize novel SMIs to inhibit the non-canonical DR-signalling pathway. In cooperation, in silico approaches will be used to develop novel TRADD inhibitors, which will enforce the apoptotic over the non-canonical DR-signalling pathway. After the synthetic accessibility evaluation of the identified inhibitors, the synthesis of potential compounds will be designed by retrosynthesis and carried out using innovative synthetic methods, such as microwave heating and flow chemistry. The biological activity and toxicity of the candidates will be verified and tested in vitro on tumour and immune cells, in cooperation.
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