Thesis supervisor: László Petri
Location of studies (in Hungarian): HUN-REN Research Centre for Natural Sciences Abbreviation of location of studies: TTK
Description of the research topic:
Antibody-drug conjugates (ADCs) are cytotoxic drug-tethered monoclonal antibodies mostly utilized by clinical applications on cancer treatments, while bispecific antibodies (bsAbs) are advanced biotherapeutics, able to bind two different antigens. However, ADC and bsAb techniques are already provided several marketed drugs, a synergetic fusion of these approaches generating bispecific antibody-drug conjugates (bsADC) are still a lack in oncology-related therapeutics. Bispecific antibody constructs are usually generated via protein engineering techniques but improved chemical methods for their synthesis have been reported recently. However, to date, the development of scalable and robust chemical conjugation process remains a highly challenging task for drug research.
Major goal of this PhD research will be to find highly effective chemical procedures to synthesize bispecific antibody-drug conjugates. The resulted methods could be beneficial due to their cost- and time-effectiveness, and furthermore, their modularity, as bsADCs could be generated from any available antibodies, without the need for protein engineering. Furthermore, we will also utilize these chemical conjugation methods to produce and apply therapeutically relevant bispecific antibody-drug conjugates in the field of gyneological oncology.
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