Thesis supervisor: Balázs Imre
Location of studies (in Hungarian): BME Department of Physical Chemistry and Materials Science Abbreviation of location of studies: BME
Description of the research topic:
We design and synthesize plant protein and synthetic proteinoid nanocarriers with glycan outer shells for the
encapsulation and controlled delivery of poorly water-soluble active substances. Poor water solubility and
bioavailability limits the efficacy of numerous active substances. Their encapsulation with nanoparticles improves
solubility and stability, enabling the use of drug candidates previously ignored due to poor pharmacokinetics.
Proteins are non-toxic, biodegradable, and metabolizable natural amphiphilic polymers that form nanoparticles by
environmentally benign self-assembly to encapsulate various compounds. Their surface can be conveniently
modified with drugs and targeting ligands. In this project, protein-glycan core-shell nanocarriers are prepared by
nanoprecipitation and enzymatic cross-linking, following green chemistry principles. In addition to their size
distribution, drug encapsulation and release characteristics, we aim to study and mitigate the immune response
induced by the nanocarriers in vivo.
Number of students who can be accepted: 1
Deadline for application: 2024-05-30
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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