 Endoplasmic reticulum stress in tumor and stromal cells THESIS TOPIC PROPOSAL Institute: University of Szeged biology Doctoral School of Biology Thesis supervisor: Mónika Csontné Kiricsi Location of studies (in Hungarian): University of Szeged, Department of Biochemistry and Molecular Biology Abbreviation of location of studies: SZTE Description of the research topic: One of the most important tasks of the endoplasmic reticulum (ER) is the post-translational modification of proteins, protein folding and quality control. However, if the cell is exposed to effects that cause a disturbed ER function, ER stress develops. Such effects may include hypoxia, nutrient deficiency, stress signals from certain sources, or artificially produced agents that induce ER stress. To defeat ER stress and restore the physiological functions of the ER, cells produce an adaptive response called "Unfolded Protein Response" (UPR), but if the stress is prolonged or excessive, UPR leads to programmed cell death. Various active substances such as nanoparticles, steroid derivatives or molecules coming from the cells of the tumor microenvironment also induce ER stress, which effects are investigated for cell biological and therapeutic purposes. Recommended language skills (in Hungarian): English Number of students who can be accepted: 1 Deadline for application: 2024-08-31 |