 Synthesis of biologically active flavonoid derivatives THESIS TOPIC PROPOSAL Institute: Budapest University of Technology and Economics bio, environmental and chemical engineering George A. Olah Doctoral School of Chemistry and Chemical Technology Thesis supervisor: Hedvig Bölcskei belső konzulens: Péter Keglevich Location of studies (in Hungarian): BME Department of Organic Chemistry and Technology Abbreviation of location of studies: BME Description of the research topic: Many of flavonoids or flavonoid derivatives show valuable biological activity, antiinflammatory or antitumor activity, e.g. the flavopiridol, the flavonoid alkaloid kinase inhibitor, received orphan drug status from FDA for the treatment of acute myeloid leukemia. Recently, our research group have synthetised a few crysin derivatives with antitumor activity. The target is to improve this compound library varyiing the starting flavonoid core, or chromane skeleton, the spacer, the amine functions and all other moieties. In synthesis of the building blocks, we would like to study the organocatalysis applying cinchona or other derivatives. The obtained compounds will be tested by National Institute of Health. Number of students who can be accepted: 1 Deadline for application: 2024-05-30 |