 Role of Exogenous and Endogenous Modifiers in the Development of Abnormal Glucose Tolerance in Cystic Fibrosis THESIS TOPIC PROPOSAL Institute: Semmelweis University, Budapest clinical medicine Doctoral School of University Semmelweis Thesis supervisor: Klementina Ocskay Location of studies (in Hungarian): Semmelweis Egyetem Abbreviation of location of studies: SE Description of the research topic: Cystic fibrosis (CF) is the most common genetic disease in the European-descent population, inherited in an autosomal recessive manner. Its development is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Impaired water and electrolyte transport in exocrine glands lead to a progressive, multi-organ disorder. The clinical picture is primarily characterized by lung involvement, but digestive system symptoms and disturbances in glucose metabolism affect a significant portion of patients, significantly influencing the course of the disease and quality of life. Cystic fibrosis-related diabetes (CFRD) is considered the most common extrapulmonary complication, affecting one-third of adolescents and nearly half of adults with CF. Diagnosis of cystic fibrosis-related abnormal glucose tolerance is recommended from the age of 10 through an annual oral glucose tolerance test (OGTT). Besides factors related to CF, numerous other factors may play a role in their development, affecting the age of onset, progression, and severity of symptoms. These include the gut microbiome, certain genetic predisposing factors, as well as islet cell autoantibodies. Deadline for application: 2024-12-31 |