 Genomic and epigenetic profiling of neuroendocrine lung tumours THESIS TOPIC PROPOSAL Institute: University of Szeged biology Doctoral School of Biology Thesis supervisor: Lőrinc Sándor Pongor co-supervisor: Gabriella Mihalekné Fűr Location of studies (in Hungarian): Cancer Genomics and Epigenetics Core Group, Hungarian Centre of Excellence for Molecular Medicine (HCEMM), Szeged, Hungary Abbreviation of location of studies: SZBK Description of the research topic: Small cell lung cancer accounts for 15% of lung tumors and is often metastatic at diagnosis. Although tumors often respond well to chemotherapeutic treatments, resistance usually develops rapidly, resulting in a short median survival of patients. During treatment, and as the tumor develops, the typical neuroendocrine phenotype and genome stability in the cells is altered, which contributes to drug resistance. Our aim is to monitor and characterize these changes, which may help improve treatment options by identifying new biomarkers. Required language skills: Hungarian or English Number of students who can be accepted: 2 Deadline for application: 2024-08-31 |