László Őrfi - ODT Personal data sheet


	Login Forum Organisation officers member institutions resolutions (in Hung.) by-laws (in Hung.) regulations Doctoral program doctoral schools by institution by research field by number ceased working academic staff member by name by research topic archives thesis topic proposals by doctoral school by research field by research topic supervision of PhD students search students Theses defended by institution by research field by name by date by doctoral school Naturalized degrees by institution by research field by name by date Habilitation presentations by institution by branch of science by name Documents (all in Hung.) public documents news legal backgrounds guidelines Contacts contact details partners

Personal data sheet

Print preview

personal data approved: 2023. XI. 14.

Personal data

name	László Őrfi
name of institution	Budapest University of Technology and Economics Semmelweis University, Budapest
doctoral school	BME George A. Olah Doctoral School of Chemistry and Chemical Technology (Academic staff member Az oktató a doktori iskola doktoranduszai számára oktat tantárgyat, és/vagy a doktori iskola megszavazta, hogy doktoranduszok számára kutatási témát írjon ki. ) (discipline) Habilitation Comittee and Doctoral Council (external member) SE Doctoral School of Molecular Medicine (Academic staff member Az oktató a doktori iskola doktoranduszai számára oktat tantárgyat, és/vagy a doktori iskola megszavazta, hogy doktoranduszok számára kutatási témát írjon ki. ) SE Doctoral School of University Semmelweis (Core member) SE Doctoral School of Pharmaceutical Sciences Council of the Doctoral School
the share of work in the different doctoral schools.	BME George A. Olah Doctoral School of Chemistry and Chemical Technology 10% SE Doctoral School of University Semmelweis 70% BME GAODSCC (discipline) Habilitation Comittee and Doctoral Council (external member) 20%
accreditation statement submitted to:	Semmelweis University, Budapest

Contact details
phone number	+36 1 217-0891
	own web page

Academic title
scientific degree, title	Ph.D.
year degree was obtained	1997
discipline to which degree belongs	chemistry
institution granting the degree	Semmelweis University
scientific degree, title	Habilitation
year degree was obtained	2013
discipline to which degree belongs	pharmaceutics
institution granting the degree	Semmelweis University

Employment
1982 -	Semmelweis University, Budapest university professor or researcher

Thesis topic supervisor

number of doctoral students supervised until now

number of students who fulfilled course requirements

students who obtained their degrees:

Anna Sipos	PhD	2021	DSPS1-SE
Rita Garamvölgyi	PhD	2017	DSPS1-SE
Ferenc Baska	PhD	2015	DSPS1-SE
Gábor Németh	PhD	2012	DSPS1-SE
Gábor Péter Bánhegyi	PhD	2009	DSPS1-SE
Csaba Szántai-Kis	PhD	2008

completed course requirement:

Marcell Krekó	(PhD)	2021/08	DSPS1-SE
Mihály Szabó	(PhD)	2020/08	DSPS1-SE
Zoltán Nemes	(PhD)	2015/08	DSPS1-SE
Zsófia Molnár Balázsné dr. Czudor	(PhD)	2018/08	DSPS1-SE

present PhD students:

Gyula Bencze

(PhD)

(2024/08)

SEDI (to be translated)

Thesis topic proposals

Research
research area	Pharmaceutical chemistry, kinase inhibitors, quantitative structure-activity relationship (QSAR, ADMET), drug design, lead optimisation, drug discovery, medicinal chemistry, paralell synthesis
research field in which current research is conducted	chemistry pharmaceutics

Publications

2024

Valdez Capuccino L., Kleitke T., Szokol B., Svajda L., Martin F., Bonechi F., Krekó M., Azami S., Montinaro A., Wang Y., Nikolov V., Kaiser L., Bonasera D., Saggau J., Scholz T., Schmitt A., Beleggia F., Reinhardt H. C., George J., Liccardi G., Walczak H., Tóvári J., Brägelmann J., Montero J., Sos M. L., Őrfi L., Peltzer N.: CDK9 inhibition as an effective therapy for small cell lung cancer, CELL DEATH AND DISEASE 15: (5) 345
type of document: Journal paper/Article
language: English
URL

2023

Hrabák András, Bögel Gábor, Murányi József, Tamási Viola, Németh Krisztina, Szokol Bálint, Kukor Zoltán, Kardon Tamás, Őrfi László: Decreasing effects of protein kinase inhibitors on the expression of NOS2 and inflammatory cytokines and on phagocytosis in rat peritoneal macrophages is partly related to repolarization, MOLECULAR IMMUNOLOGY 153: pp. 10-24.
type of document: Journal paper/Article
number of independent citations: 1
language: English
URL

2023

Szász Csenge, Pap Domonkos, Szebeni Beáta, Bokrossy Péter, Őrfi László, Szabó Attila J., Vannay Ádám, Veres-Székely Apor: Optimization of Sirius Red-Based Microplate Assay to Investigate Collagen Production In Vitro, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24: (24) 17435
type of document: Journal paper/Article
number of independent citations: 1
language: English
URL

2022

Gómez Valentí, Galazi Myria, Weitsman Gregory, Monypenny James, Al-Salemee Fahad, Barber Paul R, Ng Kenrick, Beatson Richard, Szokol Bálint, Őrfi László, Mullen Greg, Vanhaesebroeck Bart, Chowdhury Simon, Leung Hing Y., Ng Tony: HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models, MOLECULAR CANCER THERAPEUTICS 21: (4) pp. 667-676.
type of document: Journal paper/Article
number of independent citations: 5
language: English
URL

2021

Bencze Gyula, Bencze Szilvia, Rivera Keith D., Watson James D., Hidvegi Mate, Orfi Laszlo, Tonks Nicholas K., Pappin Darryl J.: Author Correction: Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth (vol 10, 14174, 2020), SCIENTIFIC REPORTS 11: (1) 3036
type of document:
language: English
URL

2018

Szabadkai I, Torka R, Garamvolgyi R, Baska F, Gyulavari P, Boros S, Illyes E, Choidas A, Ullrich A, Orfi L: Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as Novel AXL Kinase Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY 61: (14) pp. 6277-6292.
type of document: Journal paper/Article
number of independent citations: 22
language: English
URL

2016

Garamvolgyi R, Dobos J, Sipos A, Boros S, Illyes E, Baska F, Kekesi L, Szabadkai I, Szantai-Kis C, Keri G, Orfi L: Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells., EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 108: pp. 623-643.
type of document: Journal paper/Article
number of independent citations: 28
language: English
URL

2010

Petak I, Schwab R, Orfi L, Kopper L, Keri G: Integrating molecular diagnostics into anticancer drug discovery, NATURE REVIEWS DRUG DISCOVERY 9: (7) pp. 523-535.
type of document: Journal paper/Article
number of independent citations: 50
language: English
URL

2004

Ozvegy-Laczka C, Hegedus T, Varady G, Ujhelly O, Schuetz JD, Varadi A, Keri G, Orfi L, Nemet K, Sarkadi B: High-affinity interaction of tyrosine kinase inhibitors with the ABCG2multidrug transporter, MOLECULAR PHARMACOLOGY 65: (6) pp. 1485-1495.
type of document: Journal paper/Article
number of independent citations: 314
language: English
URL

1998

Orfi L, Lin MF, Larive CK: Measurement of SDS micelle-peptide association using H-1 NMR chemical shift analysis and pulsed field gradient NMR spectroscopy, ANALYTICAL CHEMISTRY 70: (7) pp. 1339-1345.
type of document: Journal paper/Article
number of independent citations: 61
language: English
URL

Number of independent citations to these publications:

482

Scientometric data

list of publications and citations

number of scientific publications that meet accreditation criteria:

338

number of scientific publications:

332

monographs and professional books:

monographs/books in which chapters/sections were contributed:

art/engineering creative works:

scientific publications published abroad that meet the accreditation criteria:

175

publications not in Hungarian, published in Hungary, meeting the accreditation criteria:

number of independent citations to scientific publications and creative works:

3977

further relevant information regarding accreditation (in Hungarian)
Inventor of more than 110 pharmaceutical patents