Thesis supervisor: Gábor Zoltán Boross
Location of studies (in Hungarian): Institute of Evolution, Centre for Ecological Research, HUN-REN Hungarian Research Network Abbreviation of location of studies: H-REN
Description of the research topic:
Cancer is a disease caused by genetic mutations. To understand the effect of each of these mutations, controlled experiments are conducted where the effect of a specific mutation is measured. However, cancers generally harbor multiple mutations and these mutations interact. This presents a problem as measuring the effect of single mutations tells us little about how tumors of complex genotypes will behave. Generating a multitude of complex genotypes (e.g. double mutants) on the other hand, especially using in vivo experimental models, is not a trivial task and therefore limits our understanding of how mutliple mutations orchestrate cancer progression.
Required language skills: English Further requirements: We are looking for candidates with M.Sc. degrees in biology, physics, mathematics, computer science or similar to join our recently founded group to do wet and/or dry lab work in the intersection of evolutionary and cancer biology.