Conformational changes of skeletal and cardiac actin/myosin under the effect of toxic agents (phalloidin and jasplaklinolide) and free radicals. A DSC approach
Thesis supervisor: Dénes Lőrinczy
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Glycerinated psoas muscle fiber is a good biochemical and mechanical model of the intact muscle. The muscle model and the intermediate states of ATP-hydrolysis cycle depend strongly on the environmental effects. Some of these stabilise the structure (e.g.: toxins) while the free radicals influence the function too through the damage of the structure. UV irradiation of hydrogen peroxide produces free radicals and these will be used to monitor the structural and functional consequences of pathological hydrolysis cycle.